Generation of a novel ex-vivo model to study re-endothelialization

Bibliographic Details
Title:	Generation of a novel ex-vivo model to study re-endothelialization
Authors:	Siti Sarah Azman, Muhammad Dain Yazid, Nur Azurah Abdul Ghani, Raja Zahratul Azma Raja Sabudin, Mohd Ramzisham Abdul Rahman, Nadiah Sulaiman
Source:	Artificial Cells, Nanomedicine, and Biotechnology, Vol 51, Iss 1, Pp 408-416 (2023)
Publisher Information:	Taylor & Francis Group, 2023.
Publication Year:	2023
Collection:	LCC:Biotechnology LCC:Medical technology
Subject Terms:	Umbilical artery, endothelial denudation, intimal hyperplasia, endothelial dysfunction, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
More Details:	AbstractEndothelial dysfunction initiates the pathogenesis of a myriad of cardiovascular diseases, yet the precise underlying mechanisms remain unclear. Current model utilises mechanical denudation of arteries resulting in an arterial-injury model with onset of intimal hyperplasia (IH). Our study shows that 5 min enzymatic denudation of human umbilical artery (hUA) lumen at 37 °C efficiently denudes hUA while maintaining vessel integrity without significantly increase intima-media thickness after 7 days in culture. This ex-vivo model will be a valuable tool in understanding the mechanism of re-endothelialization prior to smooth muscle cells (SMC) activation thus placating IH at an early stage.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	21691401 2169-141X 2169-1401
Relation:	https://doaj.org/toc/2169-1401; https://doaj.org/toc/2169-141X
DOI:	10.1080/21691401.2023.2245456
Access URL:	https://doaj.org/article/42393f2ff08b448fa56265df7d93d2eb
Accession Number:	edsdoj.42393f2ff08b448fa56265df7d93d2eb
Database:	Directory of Open Access Journals

More Details
ISSN:	21691401 2169141X
DOI:	10.1080/21691401.2023.2245456
Published in:	Artificial Cells, Nanomedicine, and Biotechnology
Language:	English