RESPONSE TO DESMOPRESSIN (DDAVP): PREOPERATIVE TESTING
| Title: | RESPONSE TO DESMOPRESSIN (DDAVP): PREOPERATIVE TESTING |
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| Authors: | Dušan Andoljšek, Tadej Pajič |
| Source: | Zdravniški Vestnik, Vol 77, Iss SUPPI (2008) |
| Publisher Information: | Slovenian Medical Association, 2008. |
| Publication Year: | 2008 |
| Collection: | LCC:Medicine |
| Subject Terms: | Medicine |
| More Details: | BACKGROUND The principle of treatment or prevention of bleeding in von Willebrand disease (vWd)is correction of dual plasma deficiency of von Willebrand factor (vWF) and factor VIII(F VIII). This can be achieved by desmopressin (DDAVP) or plasma fractions. DDAVPeffect was tested in von Willebrand patients before surgical procedure. METHODS DDAVP test was done in 13 vWd patients (type 1) by slow infusion of DDAVP (0.3 ug/bwMinirin, Ferring) in 100 ml of saline. Before, after 1, 4 hours venous blood sample wastaken for F VIII:C, vWF:Rco, vWF:CBA, vWF:Ag. RESULTS After 1 hour, preinfusion levels comparison showed, F VIII:C, vWF:CBA, vWF:Ag were 2–4times higher, vWF:RCo 2–3 times higher. 4 hours later all the levels were one third to onefourth lower but still high enough to prevent bleeding. CONCLUSIONS DDAVP raises vWF in vWd patients (except type 3) and has efficacious hemostaticresponse as it prevents or stop bleeding. Using DDAVP test, 2–4 times higher levels of F VIIIand vWF were noticed 1 hour after DDAVP infusion. The data can help us to decide theoptimal treatment to prevent and stop bleeding in vWd patients |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Slovenian |
| ISSN: | 1318-0347 1581-0224 |
| Relation: | http://vestnik.szd.si/index.php/ZdravVest/article/view/899; https://doaj.org/toc/1318-0347; https://doaj.org/toc/1581-0224 |
| Access URL: | https://doaj.org/article/ed42263a340c43a3881d3ee90f3ef489 |
| Accession Number: | edsdoj.42263a340c43a3881d3ee90f3ef489 |
| Database: | Directory of Open Access Journals |
| ISSN: | 13180347 15810224 |
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| Published in: | Zdravniški Vestnik |
| Language: | English Slovenian |