A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain
| Title: | A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain |
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| Authors: | Aina Martínez-Planas, Fernando Baquero-Artigao, Ana Méndez-Echevarría, Teresa Del Rosal, Paula Rodríguez-Molino, Carlos Toro-Rueda, Matilde Bustillo-Alonso, Miguel Lafuente, Anna Canet, Ángela Manzanares, Alfredo Tagarro, Francisco José Sanz-Santaeufemia, Sara Guillén-Martín, María José Cilleruelo, Lola Falcón-Neyra, Begoña Santiago, Elena Rincón, Miguel Lillo, Antoni Soriano-Arandes, Luigi Sedda, Clàudia Fortuny, Manuel Monsonís, Julián González-Martín, Marc Tebruegge, Antoni Noguera-Julian |
| Source: | Emerging Infectious Diseases, Vol 31, Iss 3, Pp 536-546 (2025) |
| Publisher Information: | Centers for Disease Control and Prevention, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | tuberculosis and other mycobacteria, bacteria, lymphadenitis, interferon-gamma release assay, Mycobacterium avium complex, Mycobacterium lentiflavum, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | We describe the epidemiology, diagnosis, and management of nontuberculous mycobacterial lymphadenitis cases detailed in a 28-year (1996–2023) multicenter cohort from Spain. The case numbers remained stable during the initial prospective phase (2013–2020), but a sharp decline was observed during 2021–2022. Disease onset occurred during spring or June in 45.9% of cases. Mycobacterium avium complex (43.1%) and M. lentiflavum (39.9%) were the most common species detected. M. lentiflavum affected mostly younger children from central Spain. The most common treatment strategy was complete surgical resection with (n = 80) or without (n = 88) antimicrobial drug treatment, followed by antimicrobial drugs alone (n = 76). Facial palsy developed in 10.4% of surgical cases. Adverse events because of antimicrobial drugs were uncommon. New fistula formation during follow-up occurred more in children managed with observation alone than in those treated with antimicrobial drugs alone (relative risk 2.7 [95% CI 1.3–5.3]; p = 0.014). |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/31/3/24-1254_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid3103.241254 |
| Access URL: | https://doaj.org/article/41ed859ac626428bbb78eab5f6401c28 |
| Accession Number: | edsdoj.41ed859ac626428bbb78eab5f6401c28 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid3103.241254 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |