Bibliographic Details
| Title: |
Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice |
| Authors: |
Christina Wenzek, Devon Siemes, G. Sebastian Hönes, Eva Pastille, Nina Härting, Frank Kaiser, Lars C. Moeller, Daniel R. Engel, Astrid M. Westendorf, Dagmar Führer |
| Source: |
iScience, Vol 27, Iss 8, Pp 110547- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Molecular biology, Immunology, Endocrinology, Cell biology, Science |
| More Details: |
Summary: The immune system has emerged as an important target of thyroid hormones (THs); however, the role of TH in T cells has so far remained elusive. In this study, we assessed the effect of TH receptor α (TRα) signaling on activation and function of T cells. Our findings show that lack of canonical TRα action not only increased the frequency of regulatory T cells (Treg) but propelled an activated and migratory Treg phenotype and nuclear factor κB (NF-κB) activation in Treg. Conversely, canonical TRα action reduced activation of the NF-κB pathway previously shown to play a pivotal role in Treg differentiation and function. Taken together, our findings demonstrate that TRα impacts T cell differentiation and phenotype. Given the well-known interaction of inflammation, immune responses, and TH axis in e.g., severe illness, altered TH-TRα signaling may have an important role in regulating T cell responses during disease. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224017723; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.110547 |
| Access URL: |
https://doaj.org/article/ccc41df7f60d483a819b4e87f9def24f |
| Accession Number: |
edsdoj.41df7f60d483a819b4e87f9def24f |
| Database: |
Directory of Open Access Journals |
