Bibliographic Details
| Title: |
Dietary supplementation of α-linolenic acid-rich flaxseed oil enhances anti-PD-1 protection against orthotopic hepatocellular carcinoma by reshaping gut homeostasis and improving anti-tumor immunity via gut-liver axis in mice |
| Authors: |
Jian Liu, Yiwei Li, Wenke Shen, Ting Wang, Yuanyuan Liu, Junbai Ma, Xiaoxu Zhang, Ting Li, Wenyan Tian, Xiaolong Ma, Lina Zhang, Ke Li, Ming Li, Xiaoxia Zhang, Qing Liu, Hao Wang |
| Source: |
Journal of Functional Foods, Vol 116, Iss , Pp 106157- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
α-linolenic acid, anti-PD-1 therapy, Hepatocellular carcinoma, Gut microbiota, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
Blockade therapy of immune checkpoint with anti-programmed cell death (PD)-1 antibody has achieved tremendous success on the treatment of numerous malignant tumors, whereas there is still a problem of low response rate. In the present study, the complement of α-linolenic acid (ALA) on the impact of PD-1 immunotherapy for hepatocellular carcinoma (HCC) was investigated. We found that the ALA combined with PD-1 immunotherapy exerted superior in inhibiting tumor growth. Moreover, the combination treatment significantly changed diverse T cell subsets and ant-tumor immunity associated cytokine levels in plasma and tumor tissues. Intriguingly, gut dysbiosis was notably attenuated after the intervention by elevating the expression of intestinal tight junction proteins alonged with reducing liver lipopolysaccharide (LPS), as well as modulating gut microbiota and short-chain fatty acids (SCFAs). Collectively, these results indicated that the supplement with ALA strengthened anti-tumor immunity and reshaped the gut homeostasis to contribute to the PD-1 treatment against HCC. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464624001592; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2024.106157 |
| Access URL: |
https://doaj.org/article/41bb7f7cebc0454a9b41e1507c13a172 |
| Accession Number: |
edsdoj.41bb7f7cebc0454a9b41e1507c13a172 |
| Database: |
Directory of Open Access Journals |
