Bibliographic Details
| Title: |
Do hospitalists who prescribe high (risk-adjusted) rates of antibiotics do so repeatedly? |
| Authors: |
Udodirim Onwubiko, Christina Mehta, Zanthia Wiley, Jesse Jacob, Ashley Jones, Shabir Hassan, Marybeth Sexton, Sujit Suchindran, Scott Fridkin |
| Source: |
Antimicrobial Stewardship & Healthcare Epidemiology, Vol 2, Pp s2-s2 (2022) |
| Publisher Information: |
Cambridge University Press, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Infectious and parasitic diseases
LCC:Public aspects of medicine |
| Subject Terms: |
Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| More Details: |
Background: Provider-specific prescribing metrics can be used for benchmarking and feedback to reduce unnecessary antibiotic use; however, metrics must be credible. To improve credibility of a recently described risk-adjusted antibiotic prescribing metric for hospital medicine service (HMS) providers, we assessed whether providers who initially prescribed excess antibiotics continued to prescribe antibiotics excessively. Methods: We linked administration and billing data among patients at 4 acute-care hospitals (1,571 beds) to calculate days of therapy (DOT) ordered by individual hospitalists for each of 3 NHSN antibiotic groupings: broad-spectrum hospital onset (BS-HO), broad-spectrum community-onset (BS-CO), or anti-MRSA for each patient day billed from January 2020 to June 2021. To incorporate repeated measures by provider, mixed models adjusted for patient-mix characteristics (eg, % encounters with urinary tract infection, etc) were used to calculate serial, bimonthly, provider-specific, observed-to-expected ratios (OERs). An OER of 1.25 indicates that the prescribing rate observed was 25% higher than predicted, adjusting for patient mix. We then used log binomial generalized estimating equations to assess whether a high prescribing rate (defined as an OER ≥ 1.25) for an individual provider in an earlier bimonthly period was associated with a persistent high rate for that provider in the following period. Results: Overall, 975 bimonthly periods were evaluated from 136 hospitalists. Most (58%) contributed data the entire 18-month study period. Median OERs were similar between hospitals: 0.94 (IQR, 0.65–1.28) for BS-HO antibiotic use, 0.99 (IQR, 0.73–1.24) for BS-CO antibiotic use, and 0.95 (IQR, 0.65–1.28) for anti-MRSA antibiotic use. At the individual prescriber level, roughly one-quarter of bimonthly OERs (range varied by group and hospital from 21% to 31%) were categorized as high. At 3 of the 4 hospitals, a provider with a high OER for either BS-HO or BS-CO antibiotic use in any bimonthly period was more likely to have a high OER in the subsequent period (Fig. 1). These observed risk ratios were statistically significant for BS-HO antibiotic use at only 2 hospitals: hospital A risk ratio (RR) was 1.54 (95% CI, 1.10–2.16); hospital B RR was 1.28 (95% CI, 0.90–1.82); hospital C RR was 0.76 (95% CI, 0.39–1.48); and ospital D RR was 1.71 (95% CI, 1.09–2.68). Conclusions: Our findings suggest that hospitalists with a higher than expected 2-month period of antibiotic prescribing are likely to continue to have elevated prescribing rates in the following period, particularly for BS-HO antibiotics. These findings increase the credibility of using a 2-month prescribing metric for BS-HO antibiotic stewardship efforts; further work is needed to evaluate utility for other antibiotic groupings. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2732-494X |
| Relation: |
https://www.cambridge.org/core/product/identifier/S2732494X22000584/type/journal_article; https://doaj.org/toc/2732-494X |
| DOI: |
10.1017/ash.2022.58 |
| Access URL: |
https://doaj.org/article/c41589cb034a476ca544d67eb73c2ebb |
| Accession Number: |
edsdoj.41589cb034a476ca544d67eb73c2ebb |
| Database: |
Directory of Open Access Journals |
