Bibliographic Details
| Title: |
Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general‐population study |
| Authors: |
Jan Terock, Sandra Van der Auwera, Deborah Janowitz, Katharina Wittfeld, Alexander Teumer, Hans J. Grabe |
| Source: |
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020) |
| Publisher Information: |
Wiley, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
cognitive decline, mineralocorticoid receptor, NR3C2 gene, rs2070951, rs5522, Genetics, QH426-470 |
| More Details: |
Abstract Background The mineralocorticoid receptor (MR) in the brain has a key role in the regulation of the central stress response and is associated with memory performance. We investigated whether the genetic polymorphisms rs5522 and rs2070951 of NR3C2 showed main and interactive effects with childhood trauma on memory decline. Methods Declarative memory was longitudinally assessed in 1,318 participants from the community‐dwelling Study of Health in Pomerania using the Verbal Learning and Memory Test (VLMT). In a subsample of 377 participants aged 60 and older, the Mini‐Mental Status Examination (MMSE) was additionally applied. Mean follow‐up time for the VLMT and MMSE were 6.4 and 10.7 years, respectively. Results Homozygous carriers of the G allele of rs2070951 (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2324-9269 |
| Relation: |
https://doaj.org/toc/2324-9269 |
| DOI: |
10.1002/mgg3.1345 |
| Access URL: |
https://doaj.org/article/d414fd23ec5c4548b05e27b95bddb5dc |
| Accession Number: |
edsdoj.414fd23ec5c4548b05e27b95bddb5dc |
| Database: |
Directory of Open Access Journals |
