Bibliographic Details
| Title: |
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| Authors: |
Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-10135-x |
| Access URL: |
https://doaj.org/article/4090a81f202846ada6a47e71478ee836 |
| Accession Number: |
edsdoj.4090a81f202846ada6a47e71478ee836 |
| Database: |
Directory of Open Access Journals |
