Bibliographic Details
| Title: |
Trends in antibiotic resistance of corneal pathogens: Part II. An analysis of leading bacterial keratitis isolates |
| Authors: |
Sharma Savitri, Kunimoto Derek, Rao Nagaraja, Garg Prashant, Rao Gullapalli |
| Source: |
Indian Journal of Ophthalmology, Vol 47, Iss 2, Pp 101-109 (1999) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 1999. |
| Publication Year: |
1999 |
| Collection: |
LCC:Ophthalmology |
| Subject Terms: |
Infectious keratitis, bacteria, antibiotic sensitivity, antibiotic resistance, treatment, Ophthalmology, RE1-994 |
| More Details: |
Purpose: To analyse leading bacterial keratitis pathogens for in-vitro susceptiblity to commonly used ocular antibiotics and to determine trends in antibiotic susceptibility for these pathogens. Methods: A retrospective review of microbiology records from 1991-1997 at the LV Prasad Eye Institute, Hyderabad, India identified the five leading bacterial keratitis pathogens.. Antibiotic susceptibility of corneal isolates was determined for various ocular antibiotics using the Kirby-Bauer disc-diffusion method. Results: Linear regression analyses were performed. Statistically significant trends included a 3.56% increase per year in the percentage of Staphylococcus epidermidis isolates susceptible to chloramphenicol (p = 0.032) [-6.61 - -0.51, 95% CI]; a 9.93% decrease per year in the percentage of Corynebacterium species isolates susceptible to ciprofloxacin (p = 0.050) [0 -19.86, 95% CI]; a 0.69% increase per year in the percentage of Staphylococcus aureus isolates susceptible to gentamicin (p = 0.012) [-11.35 - -2.49, 95% CI]; and a 5.53% increase per year in the percentage of Staphylococcus aureus isolates susceptible to norfloxacin (p = 0.040) [-10.66 - -0.40, 95% CI]. A trend of borderline significance included a 3.77% decrease per year in the percentage of Pseudomonas aeruginosa isolates susceptible to ciprofloxacin (p=0.064) [-0.34 - 7.89]. Conclusion: This study provides information on the trends in antibiotic susceptibility for the leading bacterial keratitis pathogens. It is hoped that this study will provide a rational approach for initial therapy, taking into account changing trends in antibiotic susceptibility |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0301-4738 |
| Relation: |
http://www.ijo.in/article.asp?issn=0301-4738;year=1999;volume=47;issue=2;spage=101;epage=109;aulast=Sharma; https://doaj.org/toc/0301-4738 |
| Access URL: |
https://doaj.org/article/e4075d83dc9f47b29ebfc1272157e279 |
| Accession Number: |
edsdoj.4075d83dc9f47b29ebfc1272157e279 |
| Database: |
Directory of Open Access Journals |
