Bibliographic Details
| Title: |
Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs |
| Authors: |
Preslav Vasilev, Savelina Popovska, Elitsa Petrova Kraevska, Martin Karamanliev, Dobromir Dimitrov, Ivelina Yordanova |
| Source: |
Dermatology Practical & Conceptual, Vol 14, Iss 3 (2024) |
| Publisher Information: |
Mattioli1885, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Dermatology |
| Subject Terms: |
squamous cell carcinoma of the skin, PD-L1, PD-1, CD8, High-risk clinicopathological factors, Dermatology, RL1-803 |
| More Details: |
Introduction: Squamous cell carcinoma of the skin (SCCs) is the second most common skin cancer with continuously increasing incidence. Programmed cell death ligand 1 (PD-L1), Programmed cell death 1 receptor (PD-1) and CD8 expression in primary SCCs has not been described in many studies. Objective: We investigated the association between PD-L1, PD-1, CD8 and clinocopathological prognostic factors for recurrence, metastasis and mortality of SCCs. Patients and Methods: Immunohistochemically stained sections of 100 primary SCCs divided in two groups according to diameter of the tumors (20mm) were assessed. Recombinant rabbit Anti-PD-L1 antibody [SP142] - C-terminal, rabbit monocloncal Anti-PD1 antibody [NAT105] and FLEX Mono Mo a Hu CD8, cl C8/144B, RTU were used. Results: We did not establish statistically significant differences between PD-L1, PD-1, CD8 expression and high-risk clinocopathological features – tumor size >20mm, depth >6mm, poor tumor cell differentiation, perineural/lymphovascular invasion, low/absent lymphocyte stromal reaction. Conclusions: In primary SCCs, the expression of PD-L1, PD-1 and CD8 is not associated with high-risk clinicopathological factors. We suggest that these immunohistochemical markers are more significant in advanced cases and metastatic tissues. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2160-9381 |
| Relation: |
https://dpcj.org/index.php/dpc/article/view/4147; https://doaj.org/toc/2160-9381 |
| DOI: |
10.5826/dpc.1403a176 |
| Access URL: |
https://doaj.org/article/403beb98d68347a399733afeb05d186b |
| Accession Number: |
edsdoj.403beb98d68347a399733afeb05d186b |
| Database: |
Directory of Open Access Journals |
