| Title: |
Update of the risk assessment of inorganic arsenic in food |
| Authors: |
EFSA Panel on Contaminants in the Food Chain (CONTAM), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús delMazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Christiane Vleminckx, Heather Wallace, Lars Barregård, Diane Benford, Karin Broberg, Eugenia Dogliotti, Tony Fletcher, Lars Rylander, José Cortiñas Abrahantes, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tuuli Tauriainen, Tanja Schwerdtle |
| Source: |
EFSA Journal, Vol 22, Iss 1, Pp n/a-n/a (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Nutrition. Foods and food supply
LCC:Chemical technology |
| Subject Terms: |
benchmark dose (BMD), epidemiological studies, inorganic arsenic (iAs), margin of exposure (MOE), risk assessment, Nutrition. Foods and food supply, TX341-641, Chemical technology, TP1-1185 |
| More Details: |
Abstract The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1831-4732 |
| Relation: |
https://doaj.org/toc/1831-4732 |
| DOI: |
10.2903/j.efsa.2024.8488 |
| Access URL: |
https://doaj.org/article/d4014f0c32b747e1a22dd5b22c842fef |
| Accession Number: |
edsdoj.4014f0c32b747e1a22dd5b22c842fef |
| Database: |
Directory of Open Access Journals |
