Bibliographic Details
| Title: |
Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene |
| Authors: |
Han Xiao, Liu Kun, Gao Fumin, Yang Mingjun, Wang Fei |
| Source: |
Open Medicine, Vol 18, Iss 1, Pp 11-6 (2023) |
| Publisher Information: |
De Gruyter, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
mir-223-3p, nfia, cardiomyocyte damage, anthracyclines, Medicine |
| More Details: |
Irreversible cardiomyopathy was caused by the therapeutic of anthracyclines in the chemotherapy of cancers. The cell apoptosis and autophagy were induced by anthracyclines in AC16 cells. MiR-223-3p ascends in anthracycline-treated AC16, but the expression of nuclear factor I-A (NFIA) was specifically down-regulated. However, the underlying molecular mechanism between NFIA and miR-223-3p is unclear now in AC16 cells. In our research, NFIA expression was dampened in AC16 cells by miR-223-3p mimics. Additionally, miR-223-3p knockdown hindered the apoptosis and autophagy in anthracycline-treated AC16. Furthermore, NFIA was predicted and verified as a miR-223-3p’s downstream target and rescued the functions of miR-223-3p. These findings illustrated that miR-223-3p advances anthracycline-stimulated cardiomyocyte damage progression by targeting NFIA, implying the promising therapeutic function of miR-223-3p on cardiomyocyte damage in cancer patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2391-5463 |
| Relation: |
https://doaj.org/toc/2391-5463 |
| DOI: |
10.1515/med-2023-0754 |
| Access URL: |
https://doaj.org/article/3f9c8f62047f4cd9a85089bd3a024abb |
| Accession Number: |
edsdoj.3f9c8f62047f4cd9a85089bd3a024abb |
| Database: |
Directory of Open Access Journals |
