Academic Journal
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
| Title: | A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment |
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| Authors: | Valentina Marotti, Yining Xu, Cécilia Bohns Michalowski, Wunan Zhang, Inês Domingues, Hafsa Ameraoui, Tom G. Moreels, Pieter Baatsen, Matthias Van Hul, Giulio G. Muccioli, Patrice D. Cani, Mireille Alhouayek, Alessio Malfanti, Ana Beloqui |
| Source: | Bioactive Materials, Vol 32, Iss , Pp 206-221 (2024) |
| Publisher Information: | KeAi Communications Co., Ltd., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Nanocarrier, GLP-2, Teduglutide, KPV, Inflammatory bowel disease, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity, via nanoparticles while simultaneously providing with immunomodulation by tailoring the nanoparticle surface. To this end, we developed hybrid lipid hyaluronate-KPV conjugated nanoparticles loaded with teduglutide for combination therapy in IBD. The nanocarriers induced (or did not induce) immunosuppression depending on the presence (or absence) of a hyaluronan-KPV functionalization. This strategy holds promise as a nanoparticle platform for combined mucosal healing and immunomodulation in IBD treatment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X23002979; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2023.09.014 |
| Access URL: | https://doaj.org/article/3f85c90a219f44b0bab7992bff6c1026 |
| Accession Number: | edsdoj.3f85c90a219f44b0bab7992bff6c1026 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2023.09.014 |
| Published in: | Bioactive Materials |
| Language: | English |