The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease
| Title: | The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease |
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| Authors: | Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen |
| Source: | Neural Regeneration Research, Vol 20, Iss 8, Pp 2361-2372 (2025) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | cyclic guanosine monophosphate adenosine monophosphate synthase, h151, interferon regulatory factor 7, m1 phenotype, neurodegenerative disease, neuroinflammation, parkinson’s disease, ru521, sting, type i interferon, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown. Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced mouse model of Parkinson’s disease and co-localizes with microglial cells. Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype. In addition, siRNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase, tumor necrosis factor α, CD16, CD32, and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1. Taken together, our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase–stimulator of interferon genes–interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson’s disease |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1673-5374 1876-7958 |
| Relation: | https://journals.lww.com/10.4103/NRR.NRR-D-23-01684; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958 |
| DOI: | 10.4103/NRR.NRR-D-23-01684 |
| Access URL: | https://doaj.org/article/3f759adcd2d54789bd893f6f0f9afce4 |
| Accession Number: | edsdoj.3f759adcd2d54789bd893f6f0f9afce4 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16735374 18767958 |
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| DOI: | 10.4103/NRR.NRR-D-23-01684 |
| Published in: | Neural Regeneration Research |
| Language: | English |