Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites
| Title: | Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites |
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| Authors: | Laura Martinez-Gili, Julie a K McDonald, Zhigang Liu, Dina Kao, Jessica R Allegretti, Tanya M Monaghan, Grace F Barker, Jesús Miguéns Blanco, Horace R T Williams, Elaine Holmes, Mark R Thursz, Julian R Marchesi, Benjamin H Mullish |
| Source: | Gut Microbes, Vol 12, Iss 1 (2020) |
| Publisher Information: | Taylor & Francis Group, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | gut microbiome, metabonomics, fecal microbiota transplant, clostridioides difficile infection, bile acids, short chain fatty acids, trimethylamine, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understood. Recent studies by our laboratory have noted the particular key importance of restoration of gut microbe-metabolite interactions in the ability of FMT to treat rCDI, including the impact of FMT upon short chain fatty acid (SCFAs) and bile acid metabolism. This includes a significant impact of these metabolites upon the life cycle of C. difficile directly, along with potential postulated additional benefits, including effects upon host immune response. In this Addendum, we first present an overview of these recent advancements in this field, and then describe additional novel data from our laboratory on the impact of FMT for rCDI upon several gut microbial-derived metabolites which had not previously been implicated as being of relevance. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1949-0976 1949-0984 19490976 |
| Relation: | https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984 |
| DOI: | 10.1080/19490976.2020.1810531 |
| Access URL: | https://doaj.org/article/3f6ec94a2aec4415a86b8766d126f15a |
| Accession Number: | edsdoj.3f6ec94a2aec4415a86b8766d126f15a |
| Database: | Directory of Open Access Journals |
| ISSN: | 19490976 19490984 |
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| DOI: | 10.1080/19490976.2020.1810531 |
| Published in: | Gut Microbes |
| Language: | English |