| Title: |
Noninvasive monitoring of liver fat during treatment with GLP‐1 analogues and SGLT‐2 inhibitors in a real‐world setting |
| Authors: |
Vasiliki Mittag‐Roussou, Stefan Wagenpfeil, Frank Lammert, Caroline S. Stokes |
| Source: |
Endocrinology, Diabetes & Metabolism, Vol 3, Iss 3, Pp n/a-n/a (2020) |
| Publisher Information: |
Wiley, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
CAP, elastography, hepatic steatosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
Abstract Introduction Patients with NAFLD have a two‐fold increased risk of diabetes, and conversely, NAFLD affects up to 80% of patients with type 2 diabetes. Due to the co‐occurrence of both diseases and the lack of approved pharmacotherapy for NAFLD, the anti‐steatogenic potential of diabetes‐related drugs is being explored. In this study, we aim to monitor liver fat noninvasively during treatment with SGLT‐2 inhibitors or GLP‐1 analogues in a real‐world setting. Methods Overall, 39 patients (49% women, age 57.7 ± 10.9 years) with type 2 diabetes and hepatic steatosis (defined by controlled attenuation parameter [CAP] values ≥ 215 dB/m) were observed for 6 months and routinely monitored with respect to hepatic fat contents and liver stiffness (VCTE); body composition (BIA); and blood biochemistry, including liver function tests (LFTs), serum lipids and glucose metabolism markers. Results Median liver fat contents were significantly (P = .026) reduced by 9% in patients taking either SGLT‐2 (n = 22) or GLP‐1 (n = 17) for 6 months (absolute median CAP decrease: −32 dB/m [−58 to 32 dB/m]). In parallel, serum ALT and γ‐GT activities decreased significantly (P = .002 and P = .049, respectively). These improvements were accompanied by significant (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-9238 |
| Relation: |
https://doaj.org/toc/2398-9238 |
| DOI: |
10.1002/edm2.131 |
| Access URL: |
https://doaj.org/article/3f1f6b1707844d12a60defccab1f3f2b |
| Accession Number: |
edsdoj.3f1f6b1707844d12a60defccab1f3f2b |
| Database: |
Directory of Open Access Journals |
