Singapore KneE osTeoarthritis CoHort (SKETCH): protocol for a multi-centre prospective cohort study

Bibliographic Details
Title: Singapore KneE osTeoarthritis CoHort (SKETCH): protocol for a multi-centre prospective cohort study
Authors: Bryan Yijia Tan, Zack Zhong Sheng Goh, Chien Joo Lim, Michelle Jessica Pereira, Su-Yin Yang, Kelvin Guoping Tan, Alvin Chin Kwong Tan, Phyllis Liang, J. Haxby Abbott, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car
Source: BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-10 (2023)
Publisher Information: BMC, 2023.
Publication Year: 2023
Collection: LCC:Diseases of the musculoskeletal system
Subject Terms: Knee Osteoarthritis, Cohort, Outcomes, Asian, Prognosis, Healthcare Utilization, Diseases of the musculoskeletal system, RC925-935
More Details: Abstract Background Knee osteoarthritis (OA) is a leading cause of global disability. The understanding of the role of psychosocial factors in knee OA outcomes is still evolving particularly in an Asian context. The primary aim of this study is to explore psychosocial factors that prognosticate short and long-term clinical outcomes, productivity, and healthcare utilization in patients with knee OA. Secondary aims are to explore the mediation and directional relationships and the role it plays in predicting the discordance between self-reported measures (SRM), physical-performance measures (PPMs) and objective clinical parameters. Methods A multi-centre prospective cohort study of community ambulant knee OA patients seeking treatment in the tertiary healthcare institutions in Singapore will be conducted. Patients with secondary arthritis, significant cognitive impairment, severe medical comorbidities or previous knee arthroplasty will be excluded. Primary clinical outcome measure is the Knee injury and OA Outcome Score-12 (KOOS-12). Baseline characteristics include sociodemographic status, arthritis status including symptom duration and radiographic severity, comorbidities and functional status through Charlson Comorbidities Index (CCI), Barthel Index (BI) and Parker Mobility Score (PMS). Psychosocial variables include social support, kinesiophobia, negative affect, self-efficacy, injustice, chronic illness shame and the built environment. Clinical outcomes include quality of life, physical performance, global assessment, satisfaction and physical activity levels. Productivity and healthcare utilization will be assessed by a modified OA Cost and Consequences Questionnaire (OCC-Q) and the Work Productivity and Activity Impairment Questionnaire (WPAI). Variables will be collected at baseline, 4, 12 months and yearly thereafter. Regression, mediation and structural equation modelling will be used for analysis. Discussion Results will allow contextualization, identification, and phenotyping of the critical (and potentially modifiable) psychosocial parameters that predict positive clinical outcomes in the OA population to guide optimization and refinement of healthcare and community. This will facilitate: 1. identification of high-risk knee OA subpopulations that will likely experience poor outcomes and 2. formulation of targeted multidisciplinary comprehensive approaches to address these psychosocial factors to optimize non-surgical treatment care, maximize functional outcomes and create more value-based care model for knee OA. Ethics and dissemination The study has been registered under clinicaltrials.gov registry (Identifier: NCT04942236).
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1471-2474
Relation: https://doaj.org/toc/1471-2474
DOI: 10.1186/s12891-023-06207-1
Access URL: https://doaj.org/article/3f0cf59f457340019dc8371641184012
Accession Number: edsdoj.3f0cf59f457340019dc8371641184012
Database: Directory of Open Access Journals
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More Details
ISSN:14712474
DOI:10.1186/s12891-023-06207-1
Published in:BMC Musculoskeletal Disorders
Language:English