Bibliographic Details
| Title: |
Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases |
| Authors: |
Olga Pacios, Lucia Blasco, Inès Bleriot, Laura Fernandez-Garcia, Mónica González Bardanca, Antón Ambroa, María López, German Bou, Maria Tomás |
| Source: |
Antibiotics, Vol 9, Iss 2, p 65 (2020) |
| Publisher Information: |
MDPI AG, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
anti-mdr strategies, anti-persistent treatments, drug repurposing, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Antibiotic failure is one of the most worrying health problems worldwide. We are currently facing an international crisis with several problematic facets: new antibiotics are no longer being discovered, resistance mechanisms are occurring in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria are hampering the successful treatment of infections. In this context, new anti-infectious strategies against multidrug-resistant (MDR) and persistent bacteria, as well as the rescue of Food and Drug Administration (FDA)-approved compounds (drug repurposing), are being explored. Among the highlighted new anti-infectious strategies, in this review, we focus on antimicrobial peptides, anti-virulence compounds, phage therapy, and new molecules. As drugs that are being repurposed, we highlight anti-inflammatory compounds, anti-psychotics, anti-helminthics, anti-cancerous drugs, and statins. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2079-6382 |
| Relation: |
https://www.mdpi.com/2079-6382/9/2/65; https://doaj.org/toc/2079-6382 |
| DOI: |
10.3390/antibiotics9020065 |
| Access URL: |
https://doaj.org/article/3f0483f5bf38428ebfe3fb5c7b5db745 |
| Accession Number: |
edsdoj.3f0483f5bf38428ebfe3fb5c7b5db745 |
| Database: |
Directory of Open Access Journals |
