Bibliographic Details
| Title: |
Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models |
| Authors: |
Xiyan Rui, Xinran Zhao, Nailian Zhang, Yuzhou Ding, Chie Seki, Maiko Ono, Makoto Higuchi, Ming-Rong Zhang, Yong Chu, Ruonan Wei, Miaomiao Xu, Chao Cheng, Changjing Zuo, Yasuyuki Kimura, Ruiqing Ni, Mototora Kai, Mei Tian, Chunyan Yuan, Bin Ji |
| Source: |
NeuroImage, Vol 303, Iss , Pp 120947- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Alzheimer's disease (AD), Amyloid, Non-Alzheimer's disease tauopathy, Single photon emission computed tomography (SPECT), Tau, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Non-invasive determination of amyloid-β peptide (Aβ) and tau deposition are important for early diagnosis and therapeutic intervention for Alzheimer's disease (AD) and non-AD tauopathies. In the present study, we investigated the capacity of a novel radioiodinated compound AD-DRK (123/125I-AD-DRK) with 50% inhibitory concentrations of 11 nM and 2 nM for Aβ and tau aggregates, respectively, as a single photon emission computed tomography (SPECT) ligand in living brains. In vitro and ex vivo autoradiography with 125I-AD-DRK was performed in postmortem human and two transgenic (Tg) mice lines with either fibrillar Aβ or tau accumulation, APP23 and rTg4510 mice. SPECT imaging of 123I-AD-DRK was performed in APP23 mice to investigate the ability of AD-DRK to visualize fibrillar protein deposition in the living brain. In-vitro autoradiogram of 125I-AD-DRK showed high specific radioactivity accumulation in the temporal cortex and hippocampus of AD patients and the motor cortex of progressive supranuclear palsy (PSP) patients enriched by Aβ and/or tau aggregates. Ex-vivo autoradiographic images also demonstrated a significant increase in 125I-AD-DRK binding in the forebrain of both APP23 and rTg450 mice compared to their corresponding non-Tg littermates. SPECT imaging successfully captured Aβ deposition in the living brain of aged APP23 mice. The present study developed a novel high-contrast SPECT agent for assisting the diagnosis of AD and non-AD tauopathies, likely benefiting from its affinity for both fibrillar Aβ and tau. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1095-9572 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1053811924004440; https://doaj.org/toc/1095-9572 |
| DOI: |
10.1016/j.neuroimage.2024.120947 |
| Access URL: |
https://doaj.org/article/c3eb9e0049d049a9923e657e7b820209 |
| Accession Number: |
edsdoj.3eb9e0049d049a9923e657e7b820209 |
| Database: |
Directory of Open Access Journals |
