Bibliographic Details
| Title: |
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils |
| Authors: |
Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein fibrils. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-32797-w |
| Access URL: |
https://doaj.org/article/ed3eab20b6124a5585faf679ec466929 |
| Accession Number: |
edsdoj.3eab20b6124a5585faf679ec466929 |
| Database: |
Directory of Open Access Journals |
