Bibliographic Details
| Title: |
The Impact of Functional Promoter Variants in Interleukin-18 on Susceptibility to Rheumatoid Arthritis in Iranian Population |
| Authors: |
Mahboubeh Ramezanzadeh, Fatemeh Khodabandehloo, Samira Alesaeidi, Seyyed Hossein Mousavi, Shahryar Sadeghi, Naeim Ehtesham, Meysam Mosallaei, Ebrahim Hazrati |
| Source: |
Advanced Biomedical Research, Vol 13, Iss 1, Pp 100-100 (2024) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine
LCC:Biology (General) |
| Subject Terms: |
autoimmune, interleukin-18, polymorphism, rheumatoid arthritis, Medicine, Biology (General), QH301-705.5 |
| More Details: |
Background: Interleukin-18 (IL-18) is recognized for its pro-inflammatory properties and plays a central role in the progression of rheumatoid arthritis (RA). The specific single-nucleotide polymorphisms (SNPs), rs1946518 (-607C>A) and rs187238 (-137G>C), that are found in the IL-18 promoter region can potentially impact the expression of the IL-18 gene. This study aimed to investigate the correlation between these two polymorphisms and RA in the Iranian population. Materials and Methods: In this study, we conducted a case–control analysis with a total of 275 subjects consisting of 135 patients with RA and 140 controls. The high-resolution melting (HRM) method, performed through real-time polymerase chain reaction, was utilized for genotyping these polymorphisms. Results: Regarding the rs1946518 polymorphism, the frequency of AA and CA genotypes and allele A was significantly greater in the control group compared to the RA group (AA vs CC; OR: 0.42; 95%CI [0.198-0.872], CA vs CC; OR: 0.57; 95%CI [0.324-1.001], A vs C; OR: 0.58; 95%CI [0.401-0.836] (P < 0.05). There was no statistically significant difference in the frequency of genotypes and allele frequencies between the control and patient groups in terms of the rs187238 polymorphism (P > 0.05). The level of both the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) was notably elevated in the patient group with CC genotype in rs1946518 (P < 0.05). Conclusion: In the rs1946518 polymorphism, the AA and AC genotypes and the A allele demonstrated protective effects in RA. Besides, the CC genotype was associated with some laboratory characteristics in the RA group. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2277-9175 |
| Relation: |
https://journals.lww.com/10.4103/abr.abr_29_24; https://doaj.org/toc/2277-9175 |
| DOI: |
10.4103/abr.abr_29_24 |
| Access URL: |
https://doaj.org/article/3e34226200d84a50b2e9139216097c82 |
| Accession Number: |
edsdoj.3e34226200d84a50b2e9139216097c82 |
| Database: |
Directory of Open Access Journals |
