| Title: |
Endometrial stromal sarcoma occurring 20 years after total hysterectomy for myomas |
| Authors: |
Yen-Feng Lu, Ben-Shian Huang, Chiung-Ru Lai, Kuan-Chin Wang, Ming-Shyen Yen, Peng-Hui Wang |
| Source: |
Gynecology and Minimally Invasive Therapy, Vol 3, Iss 1, Pp 19-22 (2014) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Gynecology and obstetrics |
| Subject Terms: |
Endometrial stromal sarcomas, Extraovarian, Extrauterine, Immunohistochemical staining, Gynecology and obstetrics, RG1-991 |
| More Details: |
Extrauterine and extraovarian endometrial stromal sarcomas (ESSs) without endometriosis are extremely rare. A 57-year-old woman had a pelvic mass. Twenty years previously, she had undergone total hysterectomy and left salpingo-oophorectomy for uterine myomas. A series of examinations, including upper and lower gastrointestinal evaluations, and tumor markers such as cancer antigen (CA)-125, CA 19-9, and carcinoembryonic antigen were all unremarkable; however, an 18-cm heterogeneous mass with strong enhancement and many surrounding engorged vessels was present in the pelvic computed tomography image. Exploratory laparotomy showed a 20-cm gray firm mass. A complete tumor excision was performed. Microscopic features showed abundant spindle cells and epithelioid-like cells with increased cellularity. Immunohistochemistry was strongly positive for CD10, FLI-1, and vimentin; weakly positive for estrogen and progesterone receptors; and negative for CD117, CD34, HMB45, alpha-inhibin, SMA, and S-100. This favored the diagnosis of ESS. The right ovary and fallopian tube, omentum, and pelvic lymph nodes were unremarkable. The patient was treated with 2-year hormone therapy (oral megestrol, 160 mg, taken daily) and radiation therapy (50.4 Gy, separated by 28 fractions). She has been disease-free for 3 years. Active management, including complete resection and hormone therapy with/without radiation is beneficial for women with extrauterine and extraovarian ESS. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2213-3070 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213307014000021; https://doaj.org/toc/2213-3070 |
| DOI: |
10.1016/j.gmit.2014.01.001 |
| Access URL: |
https://doaj.org/article/d3e1f3bbc7e34fe0a3ef6237a95b779c |
| Accession Number: |
edsdoj.3e1f3bbc7e34fe0a3ef6237a95b779c |
| Database: |
Directory of Open Access Journals |
