Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer's Disease
| Title: | Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer's Disease |
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| Authors: | Shashank Shekhar, Manjari Tripathi, A.B. Dey, Sharmistha Dey |
| Source: | Annals of the National Academy of Medical Sciences (India), Vol 58, Iss 01, Pp 022-026 (2022) |
| Publisher Information: | Thieme Medical and Scientific Publishers Pvt. Ltd., 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:General works LCC:Science |
| Subject Terms: | alzheimer's disease, serum re1 silencing transcription factor, mild cognitive impairment, surface plasmon resonance, General works, R5-130.5, Science |
| More Details: | Objectives The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer's disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods In this case–control study of 133 subjects, 49 patients with AD, 49 patients with MCI, and 35 elderly controls were recruited. The REST protein concentrations were evaluated by SPR. The resonance unit for each sample was recorded and the concentration of serum REST of study group was derived from the standard curve. All the experiments were done in triplicates. Statistical analysis was done and p-value of < 0.05 was considered as statistically significant. Results A significant difference was observed in the Montreal Cognitive Assessment score, Hindi Mental State Examination scale (HMSE) score education, disease duration, and gender among the groups. A significant (p>0.0001) difference in the duration of disease between AD and MCI was observed. It was observed that the mean concentration of serum REST was not significantly (p = 0.266) different among the groups. Conclusion This study first time evaluated the serum levels of REST in AD, MCI and age-matched elderly controls. The rest levels were similar in all groups; however, it can provide a new direction to future blood-based biomarker studies of REST. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0379-038X 2454-5635 |
| Relation: | https://doaj.org/toc/0379-038X; https://doaj.org/toc/2454-5635 |
| DOI: | 10.1055/s-0041-1731970 |
| Access URL: | https://doaj.org/article/3e0edb7d0a09496186c9c801ccf532ad |
| Accession Number: | edsdoj.3e0edb7d0a09496186c9c801ccf532ad |
| Database: | Directory of Open Access Journals |
| ISSN: | 0379038X 24545635 |
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| DOI: | 10.1055/s-0041-1731970 |
| Published in: | Annals of the National Academy of Medical Sciences (India) |
| Language: | English |