Academic Journal
Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes
| Title: | Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes |
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| Authors: | Christien M. Beez, Marion Haag, Oliver Klein, Sophie Van Linthout, Michael Sittinger, Martina Seifert |
| Source: | Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-18 (2019) |
| Publisher Information: | BMC, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Extracellular vesicles, Exosomes, Cardiac cells, Immunomodulation, CD14+ myeloid suppressive cells, Monocytes, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Background Nano-sized vesicles, so called extracellular vesicles (EVs), from regenerative cardiac cells represent a promising new therapeutic approach to treat cardiovascular diseases. However, it is not yet sufficiently understood how cardiac-derived EVs facilitate their protective effects. Therefore, we investigated the immune modulating capabilities of EVs from human cardiac-derived adherent proliferating (CardAP) cells, which are a unique cell type with proven cardioprotective features. Results Differential centrifugation was used to isolate EVs from conditioned medium of unstimulated or cytokine-stimulated (IFNγ, TNFα, IL-1β) CardAP cells. The derived EVs exhibited typical EV-enriched proteins, such as tetraspanins, and diameters mostly of exosomes ( |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | http://link.springer.com/article/10.1186/s12951-019-0504-0; https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-019-0504-0 |
| Access URL: | https://doaj.org/article/3dbf25925da74fcd858c045a8e071e92 |
| Accession Number: | edsdoj.3dbf25925da74fcd858c045a8e071e92 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14773155 |
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| DOI: | 10.1186/s12951-019-0504-0 |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |