Bibliographic Details
| Title: |
Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis |
| Authors: |
Lucia Vernerová, Martina Vokurková, Nikoleta Alchus Laiferová, Michal Nemec, Maja Špiritović, Oksana Mytiai, Sabína Oreská, Martin Klein, Kateřina Kubínová, Veronika Horváthová, Tereza Kropáčková, László Wenchich, Michal Tomčík, Jozef Ukropec, Barbara Ukropcová, Jiří Vencovský |
| Source: |
Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-15 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Myositis, Vitamin D, Muscle, Physical activity, Lipid metabolism, Mitochondria, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Abstract Background Low levels of vitamin D have been associated with several autoimmune diseases. A growing body of evidence supports the association of vitamin D with skeletal muscle damage, regeneration, and energy and lipid metabolism. The aim was to analyse vitamin D and its receptor (VDR) in the muscle tissue of patients with idiopathic inflammatory myopathies (IIM) and to relate them to clinical parameters and muscle lipid and energy metabolism. Methods Forty-six patients with IIM and 67 healthy controls (HC) were included in the study. 27 IIM patients participated in a 24-week exercise intervention. Muscle biopsies were obtained from 7 IIM patients before/after training, 13 non-exercising IIM controls, and 21 HC. Circulating concentrations of 25(OH)D and 1,25(OH)D were measured. Gene expression of VDR and CYP27B1, the enzyme converting 25(OH)D to hormonally active 1,25(OH)D, was determined by qPCR in muscle tissue and primary muscle cells. Lipid oxidative metabolism was assessed in muscle tissue (mRNA, qPCR) and primary muscle cells (radioactive assays). Results Lower levels of active 1,25(OH)D were observed in IIM patients compared with HC (mean ± SD: 125.0 ± 45.4 vs. 164.7 ± 49.2 pmol/L; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1478-6362 |
| Relation: |
https://doaj.org/toc/1478-6362 |
| DOI: |
10.1186/s13075-025-03516-9 |
| Access URL: |
https://doaj.org/article/c3dac385830842ca9634a19bdf40e2eb |
| Accession Number: |
edsdoj.3dac385830842ca9634a19bdf40e2eb |
| Database: |
Directory of Open Access Journals |
