Bibliographic Details
| Title: |
Conopeptides from Cape Verde Conus crotchii |
| Authors: |
Agostinho Antunes, Vitor Vasconcelos, Hugo Osório, Jorge Neves, Alexandre Campos |
| Source: |
Marine Drugs, Vol 11, Iss 6, Pp 2203-2215 (2013) |
| Publisher Information: |
MDPI AG, 2013. |
| Publication Year: |
2013 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Conus, cone snails, conopeptide, conotoxin, Cape Verde, Biology (General), QH301-705.5 |
| More Details: |
Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture. Here, we study Conus crotchii venom duct using a peptide mass-matching approach. The C. crotchii was collected on the Cape Verde archipelago in the Boa Vista Island. The venom was analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). About 488 molecular masses between 700 Da and 3000 Da were searched bymatching with known peptide sequences from UniProtKB protein sequence database. Through this method we were able to identify 12 conopeptides. For validation we considered the error between the experimental molecular mass (monoisotopic) and the calculated mass of less than 0.5 Da. All conopeptides detected belong to the A-, O1-, O2-, O3-, T- and D-superfamilies, which can block Ca2+ channels, inhibit K+ channels and act on nicotinic acetylcholine receptors (nAChRs). Only a few of the detected peptides have a 100% UniProtKB database similarity, suggesting that several of them could be newly discovered marine drugs. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1660-3397 |
| Relation: |
http://www.mdpi.com/1660-3397/11/6/2203; https://doaj.org/toc/1660-3397 |
| DOI: |
10.3390/md11062203 |
| Access URL: |
https://doaj.org/article/3d556a3f1a8e453391ec4cb21db6c5fd |
| Accession Number: |
edsdoj.3d556a3f1a8e453391ec4cb21db6c5fd |
| Database: |
Directory of Open Access Journals |
