Bibliographic Details
| Title: |
Established, New and Emerging Concepts in Brain Vascular Development |
| Authors: |
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran |
| Source: |
Frontiers in Physiology, Vol 12 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Physiology |
| Subject Terms: |
endothelial cell, brain, blood–brain barrier, neurovascular disease, neural stem cell, neuron, Physiology, QP1-981 |
| More Details: |
In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells compared to non-brain endothelial cells, which is revealed by single cell RNA-sequencing methodologies. We also discuss the cross talk between brain endothelial cells and neural stem cells, and their effect on each other. In terms of mechanisms, we focus exclusively on Wnt signaling and the recent developments associated with this signaling network in brain vascular patterning, and the benefits and challenges associated with strategies for targeting the brain vasculature. We end the review with a discussion on the emerging areas of meningeal lymphatics, endothelial cilia biology and novel cerebrovascular structures identified in vertebrates. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-042X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphys.2021.636736/full; https://doaj.org/toc/1664-042X |
| DOI: |
10.3389/fphys.2021.636736 |
| Access URL: |
https://doaj.org/article/3c487797f63042eea2c78c71cc4b1538 |
| Accession Number: |
edsdoj.3c487797f63042eea2c78c71cc4b1538 |
| Database: |
Directory of Open Access Journals |
