Bibliographic Details
| Title: |
Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial |
| Authors: |
Zhang Wang, Jiaqi Wu, Dongyun Li, Xuan Tang, Yue Zhao, Xiao Cai, Xianghong Chen, Xiumin Chen, Qingchun Huang, Runyue Huang |
| Source: |
Chinese Medicine, Vol 15, Iss 1, Pp 1-15 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
Rheumatoid arthritis, Biqi capsule, Methotrexate, Leflunomide, Clinical trial, Complementary therapy, Other systems of medicine, RZ201-999 |
| More Details: |
Abstract Background Biqi capsule is a traditional Chinese medicine widely used as a complementary and alternative treatment for rheumatoid arthritis (RA). The objective is to understand the efficacy, safety and mechanism of Biqi combined with methotrexate (MTX) in RA. Methods We present a randomized, controlled pilot trial on Biqi combined with MTX against patients with active RA. Seventy patients were randomized 1:1 to receive Biqi + MTX or Leflunomide (LEF) + MTX for 24 weeks, and were assessed at baseline, 4, 12 and 24 weeks. Serum and urine samples were collected for metabolomics. Results Overall, 81.2% patients in Biqi group achieved ACR20 at 24 weeks. No statistically significant differences were observed in primary or secondary outcomes between the two groups. A better safety profile was observed for Biqi with significantly fewer adverse effects reported (11.4%) compared to LEF group (40%, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1749-8546 |
| Relation: |
http://link.springer.com/article/10.1186/s13020-020-00319-9; https://doaj.org/toc/1749-8546 |
| DOI: |
10.1186/s13020-020-00319-9 |
| Access URL: |
https://doaj.org/article/e3c171c704594997a56b7cbc395d5cb5 |
| Accession Number: |
edsdoj.3c171c704594997a56b7cbc395d5cb5 |
| Database: |
Directory of Open Access Journals |
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