Academic Journal
Four high sensitivity troponin assays and mortality in US adults with cardiovascular disease: The national health and nutrition examination survey, 1999–2004
| Title: | Four high sensitivity troponin assays and mortality in US adults with cardiovascular disease: The national health and nutrition examination survey, 1999–2004 |
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| Authors: | John W. McEvoy, Dan Wang, Olive Tang, Michael Fang, Chiadi E. Ndumele, Josef Coresh, Robert H. Christenson, Elizabeth Selvin |
| Source: | American Journal of Preventive Cardiology, Vol 17, Iss , Pp 100631- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Public aspects of medicine |
| Subject Terms: | Secondary prevention, Cardiovascular disease, Biomarkers, High-sensitivity, Troponin, NHANES, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270 |
| More Details: | Objective: High sensitivity cardiac troponin (hs-cTn) may be useful to monitor residual risk in secondary prevention. Our objective was to study the correlations and comparative associations with mortality of four hs-cTn assays in US adults with known cardiovascular disease (CVD). Methods: We studied 1,211 adults with a history of CVD who participated in the National Health and Nutrition Examination Survey (NHANES) 1999–2004. Using stored samples, we measured hs-cTnT (Roche) and three hs-cTnI assays (Abbott, Siemens, and Ortho). Outcomes were all-cause and CVD mortality, with follow-up through December 31, 2019. Results: Mean age was 64 years, 48 % were female, and 80 % identified as non-Hispanic White. Pearson's correlation coefficients between hs-cTn assays ranged from 0.67 to 0.85. There were 848 deaths (365 from CVD). Among adults with a history of prior non-fatal CVD, each hs-cTn assay (log-transformed, per 1-SD) was independently associated with CVD death (HRs ranging from 1.55 to 2.16 per 1-SD, all p-values |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-6677 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666667723001721; https://doaj.org/toc/2666-6677 |
| DOI: | 10.1016/j.ajpc.2023.100631 |
| Access URL: | https://doaj.org/article/3c0b45cac19e4392af2b41b47a587516 |
| Accession Number: | edsdoj.3c0b45cac19e4392af2b41b47a587516 |
| Database: | Directory of Open Access Journals |
| ISSN: | 26666677 |
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| DOI: | 10.1016/j.ajpc.2023.100631 |
| Published in: | American Journal of Preventive Cardiology |
| Language: | English |