Bibliographic Details
| Title: |
Pomegranate (Punica granatum) Peel Inhibits the In Vitro and In Vivo Growth of Piroplasm Parasites |
| Authors: |
Rasha Eltaysh, Mohamed Abdo Rizk, Bassem Elmishmishy, Shimaa Abd El-Salam El-Sayed, Khaled Abouelnasr, Ikuo Igarashi |
| Source: |
Journal of Parasitology Research, Vol 2022 (2022) |
| Publisher Information: |
Hindawi Limited, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Infectious and parasitic diseases, RC109-216 |
| More Details: |
Pomegranate (Punica granatum) peel has seen a rapid surge in attention as a medical and nutritional product over the last decade. The impact of pomegranate peel methanolic extract monotherapy and combination therapy on the in vitro growth of Babesia (B.) bovis, B. bigemina, B. divergens, B. caballi, and Theileria (T.) equi, as well as B. microti in mice, was investigated in this work. Fluorescence-based SYBR green I assay was used for evaluating the inhibitory antibabesial efficacy of pomegranate (Punica granatum) peel against the growth of several piroplasm parasites in vitro and in vivo. Celltac α MEK-6450 computerized haematology analyzer was used for monitoring the haematological parameters of treated mice every 4 days. Pomegranate peel inhibited the in vitro growth of B. bovis, B. bigemina, B. divergens, T. equi, and B. caballi in a dose-dependent manner, with IC50 values of 154.45±23.11, 40.90±9.35, 72.71±14.77, 100±16.20, and 77.27±16.94 μg/ml, respectively. On a B. bovis culture, the in vitro inhibitory effect of pomegranate peel was amplified when it was combined with diminazene aceturate (DA). Combination therapy of pomegranate peel and a low dose of DA (15 mg kg-1) inhibited B. microti growth significantly (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2090-0031 |
| Relation: |
https://doaj.org/toc/2090-0031 |
| DOI: |
10.1155/2022/8574541 |
| Access URL: |
https://doaj.org/article/d3ba4710f24540af9d69d6bc12f73584 |
| Accession Number: |
edsdoj.3ba4710f24540af9d69d6bc12f73584 |
| Database: |
Directory of Open Access Journals |
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