Bibliographic Details
| Title: |
PCSK9 inhibitors in clinical practice: Novel directions and new experiences |
| Authors: |
Loukianos S. Rallidis, Ioannis Skoumas, Evangelos N. Liberopoulos, Charalambos Vlachopoulos, Estela Kiouri, Iosif Koutagiar, Georgia Anastasiou, Nikolaos Kosmas, Moses S. Elisaf, Dimitrios Tousoulis, Efstathios Iliodromitis |
| Source: |
Hellenic Journal of Cardiology, Vol 61, Iss 4, Pp 241-245 (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
familial hypercholesterolaemia, proprotein convertase subtilisin/kexin type 9 inhibitors, statin intolerant patient, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background: In randomized clinical trials, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) effectively reduce low-density lipoprotein-cholesterol (LDL-C) with a favorable tolerability and safety profile. Our purpose is to provide real-world data regarding the indications, efficacy and safety of PCSK9i. Methods: The cohort comprised 141 patients who attended the lipid clinic of 3 hospitals in Greece and started using PCSK9i. Patients were requested to attend the lipid clinic at 3 months and at 1 year. Results: Ninety percent of patients had heterozygous familial hypercholesterolaemia (heFH) and 75% had cardiovascular disease (CVD). A PCSK9i [evolocumab 140 mg/2 weeks (n = 82), alirocumab 75 mg/2 weeks (n = 46) and alirocumab 150 mg/2 weeks (n = 13)] was prescribed due to failure to achieve LDL-C targets despite maximum lipid-lowering therapy (LLT) in 75% of patients, while in the remaining cases, the indication was statin intolerance. The mean reduction of LDL-C at 3 months was 56.2% and remained constant at 12 months (55.8% reduction from baseline). LDL-C target was achieved by 68.1% of patients at 3 months. “Totally” intolerant to statins patients (unable to tolerate any statin dose, n = 23) showed the lowest LDL-C reduction (47.7%). Side effects attributed to treatment were reported by 14 patients (10%). The total number of patients who stopped PCSK9i at 1 year was 14 (10%) but only 2 (1.4%) discontinued treatment because of side effects (myalgias). Conclusions: Our real-world results of PCSK9i showed comparable efficacy and tolerability to those reported in clinical trials and highlighted the value of treatment with PCSK9i heFH patients not achieving LDL-C targets despite maximum LLT and high or very high risk statin intolerant patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1109-9666 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1109966619302763; https://doaj.org/toc/1109-9666 |
| DOI: |
10.1016/j.hjc.2019.10.003 |
| Access URL: |
https://doaj.org/article/3b9b21ac806d4147aeba29388eb1a6c1 |
| Accession Number: |
edsdoj.3b9b21ac806d4147aeba29388eb1a6c1 |
| Database: |
Directory of Open Access Journals |
