Bibliographic Details
| Title: |
D-galacto-D-mannan-mediated Dectin-2 activation orchestrates potent cellular and humoral immunity as a viral vaccine adjuvant |
| Authors: |
Hyeong Won Kim, Mi-Kyeong Ko, So Hui Park, Seokwon Shin, Gang Sik Kim, Dong Yun Kwak, Jong-Hyeon Park, Su-Mi Kim, Jong-Soo Lee, Min Ja Lee |
| Source: |
Frontiers in Immunology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
foot-and-mouth disease, D-galacto-D-mannan, Dectin-2 agonist, vaccine adjuvant, cellular and humoral, immune response, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
IntroductionConventional foot-and-mouth disease (FMD) vaccines have been developed to enhance their effectiveness; however, several drawbacks remain, such as slow induction of antibody titers, short-lived immune response, and local side effects at the vaccination site. Therefore, we created a novel FMD vaccine that simultaneously induces cellular and humoral immune responses using the Dectin-2 agonist, D-galacto-D-mannan, as an adjuvant.MethodsWe evaluated the innate and adaptive (cellular and humoral) immune responses elicited by the novel FMD vaccine and elucidated the signaling pathway involved both in vitro and in vivo using mice and pigs, as well as immune cells derived from these animals.ResultsD-galacto-D-mannan elicited early, mid-, and long-term immunity via simultaneous induction of cellular and humoral immune responses by promoting the expression of immunoregulatory molecules. D-galacto-D-mannan also enhanced the immune response and coordinated vaccine-mediated immune response by suppressing genes associated with excessive inflammatory responses, such as nuclear factor kappa B, via Sirtuin 1 expression.ConclusionOur findings elucidated the immunological mechanisms induced by D-galacto-D-mannan, suggesting a background for the robust cellular and humoral immune responses induced by FMD vaccines containing D-galacto-D-mannan. Our study will help to facilitate the improvement of conventional FMD vaccines and the design of next-generation FMD vaccines. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330677/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1330677 |
| Access URL: |
https://doaj.org/article/3b90da56b4b14708b2cd49053e79a674 |
| Accession Number: |
edsdoj.3b90da56b4b14708b2cd49053e79a674 |
| Database: |
Directory of Open Access Journals |
