Extension of the BIANCA biophysical model up to Fe-ions and applications for space radiation research
| Title: | Extension of the BIANCA biophysical model up to Fe-ions and applications for space radiation research |
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| Authors: | Ramos Ricardo, Embriaco Alessia, Carante Mario, Ferrari Alfredo, Sala Paola, Vercesi Valerio, Ballarini and Francesca |
| Source: | EPJ Web of Conferences, Vol 261, p 03001 (2022) |
| Publisher Information: | EDP Sciences, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Physics |
| Subject Terms: | Physics, QC1-999 |
| More Details: | BIANCA (BIophysical ANalysis of Cell death and chromosome Aberrations) is a biophysical model, implemented as a Monte Carlo code, which simulates the induction of chromosome aberrations and cell death by different monochromatic ion beams (i.e., different ion types and energy values), as well as photons. In previous works, the model predictions for cell survival and lymphocyte dicentrics along therapeutic-like ion beams have been successfully benchmarked against experimental data. With the aim of evaluating the biological damage induced by Galactic Cosmic Rays (GCR), in this study BIANCA was extended up to Fe-ions. A radiobiological database describing human skin fibroblast cell survival and lymphocyte dicentrics as a function of ion type (1≤Z≤26) and energy, as well as dose, was constructed. Afterwards, interfacing BIANCA with the FLUKA Monte Carlo transport code, a feasibility study was performed to calculate the Relative Biological Effectiveness (RBE) of Galactic Cosmic Rays, both for dicentrics and for cell survival; the results were discussed with respect to available space radiation protection limits. Following this work, BIANCA can now provide RBE predictions of cell killing, which can be related to deterministic effects, and lymphocyte dicentrics, more related to stochastic effects, for space radiation exposure. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2100-014X 20222610 |
| Relation: | https://www.epj-conferences.org/articles/epjconf/pdf/2022/05/epjconf_anpc2022_03001.pdf; https://doaj.org/toc/2100-014X |
| DOI: | 10.1051/epjconf/202226103001 |
| Access URL: | https://doaj.org/article/3b598cd8d6904b2d95c25924d48f1e52 |
| Accession Number: | edsdoj.3b598cd8d6904b2d95c25924d48f1e52 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2100014X 20222610 |
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| DOI: | 10.1051/epjconf/202226103001 |
| Published in: | EPJ Web of Conferences |
| Language: | English |