Bibliographic Details
| Title: |
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression |
| Authors: |
Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of proapoptotic protein, Bim. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-17067-x |
| Access URL: |
https://doaj.org/article/3b2da2db381e4fd0ae6f0d0669ca275b |
| Accession Number: |
edsdoj.3b2da2db381e4fd0ae6f0d0669ca275b |
| Database: |
Directory of Open Access Journals |
