Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers

Bibliographic Details
Title: Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers
Authors: Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua
Source: Journal of Ovarian Research, Vol 18, Iss 1, Pp 1-19 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Gynecology and obstetrics
Subject Terms: FLT3, PI3K/AKT pathway, Tumor-infiltrating lymphocytes (TILs), Ovarian cancer, Cervical cancer, Spatial transcriptomics, Gynecology and obstetrics, RG1-991
More Details: Abstract Background Ovarian cancers (OC) and cervical cancers (CC) have poor survival rates. Tumor-infiltrating lymphocytes (TILs) play a pivotal role in prognosis, but shared immune mechanisms remain elusive. Methods We integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to explore immune regulation in OC and CC, focusing on the PI3K/AKT pathway and FLT3 as key modulators. Seurat and Harmony were employed for batch correction and dimensionality reduction. FLT3 expression was mapped with spatial data from 10 × Genomics. Results FLT3, identified as a regulator through the PI3K/AKT pathway, showed positive correlations with T cells, NK cells, and B cells. FLT3-high regions exhibited increased immune infiltration, particularly in CC, enhancing survival outcomes. Conclusion This study provides the first spatially resolved evidence of FLT3's immune-modulatory role in OC and CC, positioning it as a promising immunotherapeutic target. FLT3-targeted strategies may offer new options for patients resistant to conventional therapies.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1757-2215
Relation: https://doaj.org/toc/1757-2215
DOI: 10.1186/s13048-025-01592-8
Access URL: https://doaj.org/article/3b2079b5ffa94a53a46d9b8a79eb2952
Accession Number: edsdoj.3b2079b5ffa94a53a46d9b8a79eb2952
Database: Directory of Open Access Journals
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More Details
ISSN:17572215
DOI:10.1186/s13048-025-01592-8
Published in:Journal of Ovarian Research
Language:English