Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease
| Title: | Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease |
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| Authors: | Osamu Kano, Ken Ikeda, Tetsuhito Kiyozuka, Konosuke Iwamoto, Hirono Ito, et al |
| Source: | Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 707-710 (2009) |
| Publisher Information: | Dove Medical Press, 2009. |
| Publication Year: | 2009 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department of Neurology, Toho University Omori Medical Center, Tokyo, JapanAbstract: We examined whether pramipexole (PPX) can influence depressive scale in normal and mild depressive parkinsonian patients. In an open study of PPX as an add-on to L-dopa therapy or single administration, 36 nondemented outpatients with Parkinson’s disease (PD) were entered first. All were in the stage II or III of Hoehn and Yahr scale (H&Y). PPX were started at 0.125 mg/day and daily doses were increased to 1.5 mg/day. At 3 months after PPX treatment, patients were re-evaluated. Hamilton Depression Rating Scale (HAM-D), Unified Parkinson’s Disease Rating Scale III, H&Y stage, and freezing of gait questionnaire were compared in patients before and after PPX treatment. These scores were significantly improved after PPX administration. There were no correlations between HAM-D and those motor functions. We suggest that PPX treatment has antidepressant effects in depressive PD patients and also ameliorates HAM-D score in nondepressive PD patients in addition to motor function.Keywords: Parkinson disease, pramipexole, motor function, depression, antidepressant effect |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1176-6328 1178-2021 95819398 |
| Relation: | http://www.dovepress.com/beneficial-effect-of-pramipexole-for-motor-function-and-depression-in--a2868; https://doaj.org/toc/1176-6328; https://doaj.org/toc/1178-2021 |
| Access URL: | https://doaj.org/article/3b0f1bb172eb465f8aefe58e95819398 |
| Accession Number: | edsdoj.3b0f1bb172eb465f8aefe58e95819398 |
| Database: | Directory of Open Access Journals |
| ISSN: | 11766328 11782021 95819398 |
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| Published in: | Neuropsychiatric Disease and Treatment |
| Language: | English |