Use of Favipiravir to Treat Lassa Virus Infection in Macaques
| Title: | Use of Favipiravir to Treat Lassa Virus Infection in Macaques |
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| Authors: | Kyle Rosenke, Heinz Feldmann, Jonna B. Westover, Patrick William Hanley, Cynthia Martellaro, Friederike Feldmann, Greg Saturday, Jamie Lovaglio, Dana P. Scott, Yousuke Furuta, Takashi Komeno, Brian B. Gowen, David Safronetz |
| Source: | Emerging Infectious Diseases, Vol 24, Iss 9, Pp 1696-1699 (2018) |
| Publisher Information: | Centers for Disease Control and Prevention, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | Lassa virus, antiviral, favipiravir, treatment, viruses, macaques, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection. We tested favipiravir in Lassa virus–viremic macaques and found that 300 mg/kg daily for 2 weeks successfully treated infection. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/24/9/18-0233_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2409.180233 |
| Access URL: | https://doaj.org/article/3aecf98e94ba4838974e7b84ddf68363 |
| Accession Number: | edsdoj.3aecf98e94ba4838974e7b84ddf68363 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid2409.180233 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |