Academic Journal
The mediating role of primary sclerosing cholangitis in the association between ulcerative colitis and hepatobiliary cancer investigated through Mendelian randomization
| Title: | The mediating role of primary sclerosing cholangitis in the association between ulcerative colitis and hepatobiliary cancer investigated through Mendelian randomization |
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| Authors: | Fangming Wang, Junhui Xiao |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | causal relationship, hepatobiliary cancer, Mendelian randomization, mediator, primary sclerosing cholangitis, ulcerative colitis, Medicine, Science |
| More Details: | Abstract This study explored the causal relationships among primary sclerosing cholangitis (PSC), ulcerative colitis (UC), and hepatobiliary cancer (HBC) by using bidirectional two-sample, two-step Mendelian randomization (MR) analysis. Genetic variants associated with PSC and UC from the FinnGen research database were used for instrumental variable-based analyses. Mediation analyses were conducted to examine the role of PSC and UC in HBC risk. The findings revealed a causal effect of genetic predisposition to UC on PSC risk (inverse-variance-weighted [IVW] analysis odds ratio [OR] 1.145, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-83085-0 |
| Access URL: | https://doaj.org/article/3aea1e658bec40f8a899225d3397151a |
| Accession Number: | edsdoj.3aea1e658bec40f8a899225d3397151a |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-83085-0 |
| Published in: | Scientific Reports |
| Language: | English |