Bibliographic Details
| Title: |
MicroRNA expression as a prognostic biomarker of tongue squamous cell carcinoma (TSCC): a systematic review and meta-analysis |
| Authors: |
Yiwei Sun, Yuxiao Li, Wenjuan Zhou, Zhonghao Liu |
| Source: |
BMC Oral Health, Vol 24, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Dentistry |
| Subject Terms: |
Tongue squamous cell carcinoma, miRNA, Prognostic, Biomarkers, Dentistry, RK1-715 |
| More Details: |
Abstract Background Recent studies have indicated that microRNA (miRNA) expression in tumour tissues has prognostic significance in Tongue squamous cell carcinoma (TSCC) patients. This study explored the possible prognostic value of miRNAs for TSCC based on published research. Methods A comprehensive literature search of multiple databases was conducted according to predefined eligibility criteria. Data were extracted from the included studies by two researchers, and HR results were determined based on Kaplan‒Meier curves according to the Tierney method. The Newcastle‒Ottawa Scale (NOS) and GRADE (Grading of Recommendations Assessment, Development, and Evaluation) pro-GDT were applied to assess the quality of all studies. Publication bias was estimated by funnel plot, Egger’s rank correlation test and sensitivity analysis. Results Eleven studies (891patients) were included, of which 6 reported up-regulated miRNAs and 7 mentioned down-regulated miRNAs. The pooled hazard ratio (HR) from the prognostic indicator overall survival (OS) was 1.34 (1.25–1.44), p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1472-6831 |
| Relation: |
https://doaj.org/toc/1472-6831 |
| DOI: |
10.1186/s12903-024-04182-0 |
| Access URL: |
https://doaj.org/article/a39cd179f55e4202941f7caf61933323 |
| Accession Number: |
edsdoj.39cd179f55e4202941f7caf61933323 |
| Database: |
Directory of Open Access Journals |
