The Recent Outbreak of COVID-19 in China During the Omicron Variant Predominance: Clinical Features and Outcomes in Patients with Autoimmune Inflammatory Rheumatic Diseases
| Title: | The Recent Outbreak of COVID-19 in China During the Omicron Variant Predominance: Clinical Features and Outcomes in Patients with Autoimmune Inflammatory Rheumatic Diseases |
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| Authors: | Yan Geng, Yong Fan, Xuerong Deng, Yu Wang, Juan Zhao, Lanlan Ji, Zhibo Song, Guangtao Li, Xiaohui Zhang, Xiaoying Sun, Hong Huang, Wenhui Xie, Zhuoli Zhang |
| Source: | Rheumatology and Therapy, Vol 10, Iss 4, Pp 1039-1053 (2023) |
| Publisher Information: | Adis, Springer Healthcare, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Diseases of the musculoskeletal system |
| Subject Terms: | Autoimmune inflammatory rheumatic diseases, COVID-19, Vaccination, Outcome, Diseases of the musculoskeletal system, RC925-935 |
| More Details: | Abstract Introduction The impact of coronavirus disease 2019 (COVID-19) on vulnerable populations with autoimmune inflammatory rheumatic diseases (AIIRDs) has been variable with variants and of great concern. Here we report the clinical features, outcomes, and risk factors for infection and hospitalization in patients with AIIRDs in the first wave of infection in China in December 2022. Methods A real-world survey was conducted in Chinese patients with AIIRDs from 8 December 2022 to 13 January 2023. The survey was distributed via internet nationwide, clinic consultation, and to inpatients at a tertiary hospital in Beijing. Clinical features, outcomes, and vaccination status were collected. Results A total of 2005 patients with AIIRDs completed the survey. There were 1690 (84.3%) patients infected and only 48.2% of patients received COVID-19 vaccination. Most of the fully vaccinated patients received inactivated COVID-19 vaccines, including Sinovac (55.6%) and Sinopharm (27.2%), followed by recombinant subunit vaccine from Zhifei Longcom (2.0%). The independent protecting factors for infection were a time interval of less than 3 months from last vaccination (OR 0.53, p = 0.037) and rheumatoid arthritis (RA) as the underlying AIIRD (OR 0.62, p = 0.041). A total of 57 out of 1690 patients (3.4%) were hospitalized for COVID, with 46 (2.7%) experiencing severe/critical course and 6 deaths (0.4%). In multivariable logistic regression analysis, independent risk factors for hospitalization were age over 60 years (OR 11.52, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2198-6576 2198-6584 |
| Relation: | https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584 |
| DOI: | 10.1007/s40744-023-00569-7 |
| Access URL: | https://doaj.org/article/390b82a0add249ecbaa5226f9638e7f1 |
| Accession Number: | edsdoj.390b82a0add249ecbaa5226f9638e7f1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21986576 21986584 |
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| DOI: | 10.1007/s40744-023-00569-7 |
| Published in: | Rheumatology and Therapy |
| Language: | English |