Bibliographic Details
| Title: |
Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| Authors: |
Zhenzhen Ye, Jianfeng Yi, Xiangyan Jiang, Wengui Shi, Hao Xu, Hongtai Cao, Long Qin, Lixin Liu, Tianming Wang, Zhijian Ma, Zuoyi Jiao |
| Source: |
Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-21 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Gastric cancer, SERPINE1/PAI-1, let-7 g-5p, Cancer-derived exosome, M2 polarization, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Highlights SERPINE1 mediates the transfer of cancer-derived exosomal let-7 g-5p to promote macrophage M2 polarization. Exosomal let-7 g-5p drives M2 polarization by downregulating SOCS7 and relieving its inhibition of STAT3 phosphorylation. SERPINE1 promotes the transcription of let-7 g-5p by activating the JAK2/STAT3 signaling pathway. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-9966 |
| Relation: |
https://doaj.org/toc/1756-9966 |
| DOI: |
10.1186/s13046-024-03269-4 |
| Access URL: |
https://doaj.org/article/39029d9005354e81ab647c6edc40694f |
| Accession Number: |
edsdoj.39029d9005354e81ab647c6edc40694f |
| Database: |
Directory of Open Access Journals |
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