Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues

Bibliographic Details
Title:	Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues
Authors:	Daiki Hashimoto, Kota Fujimoto, Masanori Nakata, Takuya Suzuki, Shinji Kumegawa, Yuko Ueda, Kentaro Suzuki, Shinichi Asamura, Gen Yamada
Source:	Reproductive Medicine and Biology, Vol 23, Iss 1, Pp n/a-n/a (2024)
Publisher Information:	Wiley, 2024.
Publication Year:	2024
Collection:	LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Reproduction
Subject Terms:	androgen, corpus cavernosum, ED, erection, external genitalia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Reproduction, QH471-489
More Details:	Abstract Background Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental functions also for erectile tissue (corporal body) development and its abnormalities. The current review focuses on such signals from developmental and functional viewpoints. Methods Experimental strategies including histological and molecular signal analyses with conditional mutant mice for androgen and Wnt signals have been extensively utilized. Main findings Essential roles of androgen for the development of male‐type ExG and urethral formation are shown. Wnt signals are associated with androgen for male‐type ExG organogenesis. Androgen plays essential roles in the development of erectile tissue, the corporal body and it also regulates the duration time of erection. Wnt and other signals are essential for the regulation of mesenchymal cells of erectile tissue as shown by its conditional mutant mouse analyses. Stress signals, continuous erection, and the potential of lymphatic characteristics of the erectile vessels with sinusoids are also shown. Conclusion Reiterated involvement of androgen, Wnt, and other regulatory factors is stated for the development and pathogenesis of ExG and erectile tissues.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1447-0578 1445-5781
Relation:	https://doaj.org/toc/1445-5781; https://doaj.org/toc/1447-0578
DOI:	10.1002/rmb2.12611
Access URL:	https://doaj.org/article/38c4dd34b6dd4d9fbddad9b730ff6702
Accession Number:	edsdoj.38c4dd34b6dd4d9fbddad9b730ff6702
Database:	Directory of Open Access Journals
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More Details
ISSN:	14470578 14455781
DOI:	10.1002/rmb2.12611
Published in:	Reproductive Medicine and Biology
Language:	English