The Dual Regulatory Role of MiR-181a in Breast Cancer
| Title: | The Dual Regulatory Role of MiR-181a in Breast Cancer |
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| Authors: | Chun Yang, Seyed Nasrollah Tabatabaei, Xiangyan Ruan, Pierre Hardy |
| Source: | Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 843-856 (2017) |
| Publisher Information: | Cell Physiol Biochem Press GmbH & Co KG, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Physiology LCC:Biochemistry |
| Subject Terms: | Breast cancer, MiR-181a, Biomarker, Oncomir, Anti-oncomir, Prognosis, Extracellular miRNA (ex-miRNA), Ex-miR-181a, Physiology, QP1-981, Biochemistry, QD415-436 |
| More Details: | MicroRNAs (miRNAs) are a family of highly conserved noncoding singleË—stranded RNA molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post-transcriptional level and have been shown to have important roles in oncogenesis, invasion, and metastasis via epigenetic post-transcriptional gene regulation. Recent evidence indicates that the expression of miR-181a is altered in breast tumor tissue and in the serum of patients with breast cancer. However, there are several contradicting findings that challenge the biological significance of miR-181a in tumor development and metastasis. In fact, some studies have implicated miR-181a in regulating breast cancer gene expression. Here we summarize the current literature demonstrating established links between miR-181a and human breast cancer with a focus on recently identified mechanisms of action. This review also aims to explore the potential of miR-181a as a diagnostic and/or prognostic biomarker for breast cancer and to discuss the contradicting data regarding its targeting therapeutics and the associated challenges. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1015-8987 1421-9778 |
| Relation: | https://www.karger.com/Article/FullText/485351; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778 |
| DOI: | 10.1159/000485351 |
| Access URL: | https://doaj.org/article/389b870d1c8d4dba889e3805ecf47641 |
| Accession Number: | edsdoj.389b870d1c8d4dba889e3805ecf47641 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10158987 14219778 |
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| DOI: | 10.1159/000485351 |
| Published in: | Cellular Physiology and Biochemistry |
| Language: | English |