Bibliographic Details
| Title: |
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease |
| Authors: |
Bong Jin Ko, Young Seok Kim, Sang Gyune Kim, Jung Hwan Park, Sae Hwan Lee, Soung Won Jeong, Jae Young Jang, Hong Soo Kim, Boo Sung Kim, Sun Mi Kim, Young Don Kim, Gab Jin Cheon, Bo Ra Lee |
| Source: |
Gut and Liver, Vol 10, Iss 5, Pp 818-825 (2016) |
| Publisher Information: |
Gastroenterology Council for Gut and Liver, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
25-hydroxyvitamin d deficiency, transient elastography, liver stiffness, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Background/AimsDeficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD.Methods : Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant.Results : The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1976-2283 |
| Relation: |
http://gutnliver.org/journal/view.html?doi=10.5009/gnl15331; https://doaj.org/toc/1976-2283 |
| DOI: |
10.5009/gnl15331 |
| Access URL: |
https://doaj.org/article/388adb0b2d5f4fa586bfe2db97a299f4 |
| Accession Number: |
edsdoj.388adb0b2d5f4fa586bfe2db97a299f4 |
| Database: |
Directory of Open Access Journals |
