Bibliographic Details
| Title: |
Cardiometabolic and immune response to exercise training in patients with metabolic syndrome: retrospective analysis of two randomized clinical trials |
| Authors: |
Katharina Lechner, Sylvia Kia, Pia von Korn, Sophia M. Dinges, Stephan Mueller, Arnt-Erik Tjønna, Ulrik Wisløff, Emeline M. Van Craenenbroeck, Burkert Pieske, Volker Adams, Axel Pressler, Ulf Landmesser, Martin Halle, Nicolle Kränkel |
| Source: |
Frontiers in Cardiovascular Medicine, Vol 11 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
metabolic sydrome, exercise training, cardiovascular risk factor control, inflammation, cardiorespiratory fitness, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
BackgroundMetabolic syndrome (MetS) is defined by the presence of central obesity plus ≥two metabolic/cardiovascular risk factors (RF), with inflammation being a major disease-driving mechanism. Structured endurance exercise training (ET) may positively affect these traits, as well as cardiorespiratory fitness (V̇O2peak).AimsWe explore individual ET-mediated improvements of MetS-associated RF in relation to improvements in V̇O2peak and inflammatory profile.MethodsMetS patients from two randomized controlled trials, ExMET (n = 24) and OptimEx (n = 34), had performed 4- or 3-months supervised ET programs according to the respective trial protocol. V̇O2peak, MetS-defining RFs (both RCTs), broad blood leukocyte profile, cytokines and plasma proteins (ExMET only) were assessed at baseline and follow-up. Intra-individual changes in RFs were analysed for both trials separately using non-parametric approaches. Associations between changes in each RF over the exercise period (n-fold of baseline values) were correlated using a non-parametrical approach (Spearman). RF clustering was explored by uniform manifold approximation and projection (UMAP) and changes in RF depending on other RF or exercise parameters were explored by recursive partitioning.ResultsFour months of ET reduced circulating leukocyte counts (63.5% of baseline, P = 8.0e-6), especially effector subtypes. ET response of MetS-associated RFs differed depending on patients’ individual RF constellation, but was not associated with individual change in V̇O2peak. Blood pressure lowering depended on cumulative exercise duration (ExMET: ≥102 min per week; OptimEx-MetS: ≥38 min per session) and baseline triglyceride levels (ExMET: |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2297-055X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcvm.2024.1329633/full; https://doaj.org/toc/2297-055X |
| DOI: |
10.3389/fcvm.2024.1329633 |
| Access URL: |
https://doaj.org/article/c38112165f794ac9b20e315531e45ac9 |
| Accession Number: |
edsdoj.38112165f794ac9b20e315531e45ac9 |
| Database: |
Directory of Open Access Journals |
