Small molecule inhibition of RNA binding proteins in haematologic cancer
| Title: | Small molecule inhibition of RNA binding proteins in haematologic cancer |
|---|---|
| Authors: | Amit K. Jaiswal, Michelle L. Thaxton, Georgia M. Scherer, Jacob P. Sorrentino, Neil K. Garg, Dinesh S. Rao |
| Source: | RNA Biology, Vol 21, Iss 1, Pp 276-289 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Genetics |
| Subject Terms: | RNA binding proteins, post-transcriptional gene regulation, drug discovery, Acute leukaemia, RNA splicing, Genetics, QH426-470 |
| More Details: | In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have emerged as important regulator of RNA homoeostasis that are often dysregulated in the disease state. Having established the importance of these pathogenetic mechanisms, there have been a number of efforts to target RNA binding proteins using oligonucleotide-based strategies, as well as with small organic molecules. The field is at an exciting inflection point with the convergence of biomedical knowledge, small molecule screening strategies and improved chemical methods for synthesis and construction of sophisticated small molecules. Here, we review the mechanisms of post-transcriptional gene regulation, specifically in leukaemia, current small-molecule based efforts to target RNA binding proteins, and future prospects. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 15476286 1555-8584 1547-6286 |
| Relation: | https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584 |
| DOI: | 10.1080/15476286.2024.2303558 |
| Access URL: | https://doaj.org/article/37f8ee50b32748519cd1e2eefcd9acb6 |
| Accession Number: | edsdoj.37f8ee50b32748519cd1e2eefcd9acb6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 15476286 15558584 |
|---|---|
| DOI: | 10.1080/15476286.2024.2303558 |
| Published in: | RNA Biology |
| Language: | English |