Virulent Strain of Hepatitis E Virus Genotype 3, Japan
| Title: | Virulent Strain of Hepatitis E Virus Genotype 3, Japan |
|---|---|
| Authors: | Kazuaki Takahashi, Hiroaki Okamoto, Natsumi Abe, Manri Kawakami, Hiroyuki Matsuda, Satoshi Mochida, Hiroshi Sakugawa, Yoshiki Suginoshita, Seishiro Watanabe, Kazuhide Yamamoto, Yuzo Miyakawa, Shunji Mishiro |
| Source: | Emerging Infectious Diseases, Vol 15, Iss 5, Pp 704-709 (2009) |
| Publisher Information: | Centers for Disease Control and Prevention, 2009. |
| Publication Year: | 2009 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | Zoonoses, viruses, hepatitis E virus, acute hepatitis, helicase domain, JIO strain, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/15/5/08-1100_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid1505.081100 |
| Access URL: | https://doaj.org/article/37f0d26378db4f4aa140f5f34dd16574 |
| Accession Number: | edsdoj.37f0d26378db4f4aa140f5f34dd16574 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
|---|---|
| DOI: | 10.3201/eid1505.081100 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |