Bibliographic Details
| Title: |
Genetic Analysis of a Family with Multiple Incidences of Prostate Cancer |
| Authors: |
Ninghan Feng, Fengping Liu, Xinyu Xu, Yang Wang, Qingsong Sheng, Kuichun Zhu |
| Source: |
Case Reports in Oncology, Vol 15, Iss 1, Pp 86-90 (2022) |
| Publisher Information: |
Karger Publishers, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
prostate cancer, predisposition, genetic, mutation, germline, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
A family with multiple members diagnosed with prostate cancer was identified, and genetic variants were analyzed. Three brothers were diagnosed with prostate cancer. Germline variants in BRCA1, BRCA2, TINF2, and CD19 were found through next-generation DNA sequencing using a hereditary cancer panel. The BRCA1 G275D variant was present in patients, but absent in the healthy member. An ELAC2 variant was found in 1 patient. Several mutations were predicted to be deleterious by a set of computation programs. Multiple gene mutations might contribute to the overall predisposition to prostate cancer in the family. Even in cases with potentially deleterious variants in BRCA1 or BRCA2, there could be diverse clinical manifestations. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-6575 |
| Relation: |
https://www.karger.com/Article/FullText/521122; https://doaj.org/toc/1662-6575 |
| DOI: |
10.1159/000521122 |
| Access URL: |
https://doaj.org/article/37d78464f5d34c50b46d2b779f6f91cf |
| Accession Number: |
edsdoj.37d78464f5d34c50b46d2b779f6f91cf |
| Database: |
Directory of Open Access Journals |
