Bibliographic Details
| Title: |
Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats |
| Authors: |
Mareike Fauser, Jan Philipp Payonk, Hanna Weber, Meike Statz, Christine Winter, Ravit Hadar, Revathi Appali, Ursula van Rienen, Moritz D. Brandt, Alexander Storch |
| Source: |
Frontiers in Cellular Neuroscience, Vol 18 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
deep brain stimulation, subthalamic nucleus, entopeduncular nucleus, Parkinson’s disease, 6-hydroxydopamine, adult neurogenesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
IntroductionDeep brain stimulation (DBS) is a highly effective treatment option in Parkinson’s disease. However, the underlying mechanisms of action, particularly effects on neuronal plasticity, remain enigmatic. Adult neurogenesis in the subventricular zone-olfactory bulb (SVZ-OB) axis and in the dentate gyrus (DG) has been linked to various non-motor symptoms in PD, e.g., memory deficits and olfactory dysfunction. Since DBS affects several of these non-motor symptoms, we analyzed the effects of DBS in the subthalamic nucleus (STN) and the entopeduncular nucleus (EPN) on neurogenesis in 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rats.MethodsIn our study, we applied five weeks of continuous bilateral STN-DBS or EPN-DBS in 6-OHDA-lesioned rats with stable dopaminergic deficits compared to 6-OHDA-lesioned rats with corresponding sham stimulation. We injected two thymidine analogs to quantify newborn neurons early after DBS onset and three weeks later. Immunohistochemistry identified newborn cells co-labeled with NeuN, TH and GABA within the OB and DG. As a putative mechanism, we simulated the electric field distribution depending on the stimulation site to analyze direct electric effects on neural stem cell proliferation.ResultsSTN-DBS persistently increased the number of newborn dopaminergic and GABAergic neurons in the OB but not in the DG, while EPN-DBS does not impact neurogenesis. These effects do not seem to be mediated via direct electric stimulation of neural stem/progenitor cells within the neurogenic niches.DiscussionOur data support target-specific effects of STN-DBS on adult neurogenesis, a putative modulator of non-motor symptoms in Parkinson’s disease. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-5102 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fncel.2024.1396780/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2024.1396780 |
| Access URL: |
https://doaj.org/article/37a10abed87647929cac74993b9ca23e |
| Accession Number: |
edsdoj.37a10abed87647929cac74993b9ca23e |
| Database: |
Directory of Open Access Journals |
