Bibliographic Details
| Title: |
Allergic bronchopulmonary aspergillosis in a patient with ankylosing spondylitis treated with adalimumab |
| Authors: |
Yudai Suzuki, Naoki Takasaka, Sachi Matsubayashi, Ayako Kojima, Kyota Shinfuku, Tsukasa Hasegawa, Masami Yamada, Ikumi Fujisaki, Aya Seki, Yoshitaka Seki, Takeo Ishikawa, Kazuyoshi Kuwano |
| Source: |
Respirology Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021) |
| Publisher Information: |
Wiley, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Adalimumab, allergic bronchopulmonary aspergillosis, ankylosing spondylitis, anti‐tumour necrosis factor‐α antibody, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract We herein report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man treated with adalimumab for ankylosing spondylitis (AS). A 69‐year‐old man with a history of ankylosing spondylitis treated by adalimumab, an anti‐tumour necrosis factor‐α (TNF‐α) antibody, developed cough and wheezing. Chest computed tomography showed obstruction of dilated left upper lobe bronchus by high attenuation mucus as well as central bronchiectasis. Both Aspergillus‐specific immunoglobulin E (IgE) and Aspergillus precipitating antibody were positive and Aspergillus fumigatus was detected in a sputum culture. According to the new diagnostic criteria, the patient was diagnosed with ABPA. His condition rapidly improved after the withdrawal of adalimumab and initiation of prednisolone and itraconazole. Anti‐TNF‐α antibody might cause ABPA through both aggravation of the host's T‐helper 2 immunological response and anti‐fungal response. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2051-3380 |
| Relation: |
https://doaj.org/toc/2051-3380 |
| DOI: |
10.1002/rcr2.805 |
| Access URL: |
https://doaj.org/article/a3739e1bf5434725bdc9de241fcc17e6 |
| Accession Number: |
edsdoj.3739e1bf5434725bdc9de241fcc17e6 |
| Database: |
Directory of Open Access Journals |
